René Angélil, husband of Celine Dion, has died, his rep confirmed exclusively to PEOPLE on Thursday.
"Rene Angelil, 73, passed away this morning at his home in Las Vegas after a long and courageous battle against cancer," the rep said in a statement. "The family requests that their privacy be respected at the moment."
Angélil, who guided Dion's career as her manager and mentor, is survived by the couple's three children – René-Charles, 14, and 5-year-old twins Nelson and Eddy – and his adult children from a previous relationship, Anne-Marie, Patrick and Jean-Pierre.
"Mr. Angelil, 73, died of throat cancer at his home in Henderson while under the care of a physician," the Clark County Office of the Coroner/Medical Examiner said in a statement to PEOPLE.
The coroner's office added that Angélil's death was due to natural causes and no further investigation into his death was expected.