Celine Dion‘s Husband of 21 Years, Rene Angelil, Has Died

René Angélil, husband of Celine Dion, has died, his rep confirmed exclusively to PEOPLE on Thursday. 

"Rene Angelil, 73, passed away this morning at his home in Las Vegas after a long and courageous battle against cancer," the rep said in a statement. "The family requests that their privacy be respected at the moment." 

Angélil, who guided Dion's career as her manager and mentor, is survived by the couple's three children – René-Charles, 14, and 5-year-old twins Nelson and Eddy – and his adult children from a previous relationship, Anne-Marie, Patrick and Jean-Pierre.

"Mr. Angelil, 73, died of throat cancer at his home in Henderson while under the care of a physician," the Clark County Office of the Coroner/Medical Examiner said in a statement to PEOPLE. 

The coroner's office added that Angélil's death was due to natural causes and no further investigation into his death was expected. 

[Story via: People]